Primary neoplasms in dog liver induced by diethylnitrosamine.
نویسندگان
چکیده
Clinicopathological, angiographie, and histological stud ies were made on liver neoplasms in adult male mongrel dogs after administration of diethylnitrosamine. Primary hepatic neoplasms of various types developed in 14 male mongrel dogs upon administration of diethylnitrosamine for over 50 weeks. Grossly, the surface of the liver of these animals appeared finely granular, rubbery, and hard. Single or multiple gray or yellowish tumors with areas of hemor rhage 1 to 9 cm in diameter were found in the livers. Clinocopathological analysis showed that the erythrocyte count, hematocrit, and hemoglobin content of the dogs gradually decreased during administration of diethylnitros amine while the alkaline phosphatase activity and serum cholesterol level gradually increased. Malignant neoplasms of the liver were detectable by angiography in animals before sacrifice, and hemangiomas and hemangioendotheliomas were easily diagnosed by selective hepatic angiogra phy. The liver neoplasms were of the following histological types: 3 fibromas, 4 leiomyomas, 1 hemangioma, 10 hemangioendotheliomas, 4 fibrosarcomas, 2 leiomyosarcomas, 1 hepatocellular carcinoma, 1 cholangiocarcinoma, and 1 undifferentiated cell carcinoma. In nonnodular areas of the livers, oval cell infiltration, bile duct proliferation, fibrosis in periportal areas, and development of nodular hyperplasias were usually observed.
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عنوان ژورنال:
- Cancer research
دوره 34 8 شماره
صفحات -
تاریخ انتشار 1974